Construction of transmembrane protein database and topology analysis
نویسندگان
چکیده
منابع مشابه
Transmembrane Topology Pattern and Detection of Transmembrane Protein Functions
Transmembrane (TM) proteins (TMPs) have important roles in the biological organisms [1, 2]. With the rapid increasing of the number of TMPs, a lot of efforts are made in attempt to classify TMP functions by sequence analysis, and in fact, some databases aimed for it have been constructed (e.g., Pfam [3]). Which characteristics of TMP could provide us important clues to its function? We suppose ...
متن کاملConstruction of a Membrane Protein Database and an Evaluation of Several Prediction Methods of Transmembrane Segments
How reliable and useful are predictions of transmembrane segments(TMSs) of membrane proteins from the amino acid sequences? It remains still under debate. Kyte and Doolittle proposed a simple scheme for the prediction of TMSs [1]. It is based on the hydropathy plot and is widely accepted as a basic and standard method. Since then, a large number of more sophisticated predictive algorithms have ...
متن کاملConstruction and Analysis of Tissue-Specific Protein-Protein Interaction Networks in Humans
We have studied the changes in protein-protein interaction network of 38 different tissues of the human body. 123 gene expression samples from these tissues were used to construct human protein-protein interaction network. This network is then pruned using the gene expression samples of each tissue to construct different protein-protein interaction networks corresponding to different studied ti...
متن کاملMPtopo: A database of membrane protein topology.
The reliability of the transmembrane (TM) sequence assignments for membrane proteins (MPs) in standard sequence databases is uncertain because the vast majority are based on hydropathy plots. A database of MPs with dependable assignments is necessary for developing new computational tools for the prediction of MP structure. We have therefore created MPtopo, a database of MPs whose topologies ha...
متن کاملAnalysis of the processing and transmembrane topology of the E2p7 protein of hepatitis C virus.
Hepatitis C virus C, E1, E2 and p7 proteins are cleaved from a viral polyprotein by host signal peptidases. Cleavage at the E2/p7 site is incomplete in genotype 1a strain H (resulting in E2, p7 and E2p7 species), although it has been reported to be more efficient in genotype 1b strain BK. Here, the proteolytic processing and transmembrane topology of genotype 1a strain H77c p7 was investigated ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 1999
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.39.s115_4